Evaluating the Efficiency of Industrialization Process in Prefabricated Residential Buildings Using a Fuzzy Multicriteria Decision-Making Method

To alleviate the housing pressure and achieve a sustainable society, prefabricated residential building (PRB) has witnessed rapid growth in recent years. The usage of prefabricated components in the building represents a significant indicator that is traditionally used to differentiate the PRB from the traditional building. However, it cannot provide details on the efficiency of the industrialization process in the PRB. The main goal of this paper is to develop a composite index to measure the multidimensional concept of industrialization efficiency. Fuzzy Analytic Hierarchy Process (fuzzy AHP) and fuzzy Technique for Order Preference by Similarity to Ideal Solution (fuzzy TOPSIS) are applied to combine the hierarchical structure of indicators into one overall index. Finally, the industrialization efficiency assessment of three PRBs is chosen as a case to illustrate the effectiveness of the method. It can effectively quantify experts’ linguistic expressions on the performance of the PRB in different established indicators. This research can provide a decision support tool to assess and continuously promote the improvement of industrialization production in the housing industry

The impact of supervisor–worker relationship on workers’ safety violations: a modified theory of planned behaviour

This study develops and tests an integrative model to better understand the mechanisms by which the leadermember exchange (LMX) determines workers’ safety behaviours. The modified theory of planned behaviour (TPB) was proposed by using attitudinal ambivalence to replace univalent safety attitude. Empirical data were collected from 229 construction workers in China using a detailed questionnaire. Both situational and routine safety violations were considered in this model. The results showed that LMX had significant effects on both types of safety violations through three mediators from the modified TPB framework. Specifically, attitudinal ambivalence and group safety norm mediated the relationships between LMX and both types workers’ safety violations. However, perceived behavioural control only mediated the relationship between LMX and individuals’ routine safety violations. Furthermore, this research supported the distinctions between situational and routine safety violations. The indirect effects of LMX on individuals’ situational safety violations took place mainly through group safety norm. By contrast, the indirect effects on individuals’ routine safety violations took place mainly through attitudinal ambivalence and perceived behavioural control. Finally, the theoretical and practical implications, research limitations, and future directions were discussed. The results provide some meaningful insights into how to improve safety compliance behaviours from the perspective of supervisor-worker relationships

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

An Evaluation Model for Urban Comprehensive Carrying Capacity: An Empirical Case from Harbin City

Urbanization has brought notable benefits for cities, but has also resulted in severe and diverse challenges in China. Previous studies have contributed to the definitions and evaluation of urbanization. However, there remain a great deal of ambiguities regarding urban comprehensive carrying capacity, and its measurable indicators still need further exploration given the urban development. This study aims to explore a model for evaluating urban comprehensive carrying capacity and thus to promote urban development. A total of 48 indicators which fell into 8 subsystems were identified to evaluate the urban comprehensive carrying capacity through literature reviews and interviews. The indicator set was developed for evaluation indicator selecting. Meanwhile, the dynamic system was explored, and an evaluation model based on the entire array polygon method was designed to evaluate urban comprehensive carrying capacity. Finally, a case study was conducted to provide suggestions for the decision-maker to implement the evaluation model. The results of this study show that the evaluation indicator system was dynamic due to urban development. Meanwhile, the model of the entire array polygon method was able to effectively evaluate urban comprehensive carrying capacity through the case study. Furthermore, this study found that there is an imbalance among subsystems in urban development according to the standard deviation. The findings are useful for setting up a benchmark framework for urban sustainability and providing an evaluation and monitoring model for decision maker to improve the urban carrying capacity

Understanding the Social Contagion Effect of Safety Violations within a Construction Crew: A Hybrid Approach Using System Dynamics and Agent-Based Modeling

Previous research has recognized the importance of eliminating safety violations in the context of a social group. However, the social contagion effect of safety violations within a construction crew has not been sufficiently understood. To address this deficiency, this research aims to develop a hybrid simulation approach to look into the cognitive, social, and organizational aspects that can determine the social contagion effect of safety violations within a construction crew. The hybrid approach integrates System Dynamics (SD) and Agent-based Modeling (ABM) to better represent the real world. Our findings show that different interventions should be employed for different work environments. Specifically, social interactions play a critical role at the modest hazard levels because workers in this situation may encounter more ambiguity or uncertainty. Interventions related to decreasing the contagion probability and the safety⁻productivity tradeoff should be given priority. For the low hazard situation, highly intensive management strategies are required before the occurrence of injuries or accidents. In contrast, for the high hazard situation, highly intensive proactive safety strategies should be supplemented by other interventions (e.g., a high safety goal) to further control safety violations. Therefore, this research provides a practical framework to examine how specific accident prevention measures, which interact with workers or environmental characteristics (i.e., the hazard level), can influence the social contagion effect of safety violations

Demographic Influences on Perceived Stressors of Construction Workers during the COVID-19 Pandemic

Construction work is one of the most stressful occupations in the world, and the COVID-19 pandemic has only exacerbated this reality. This research conducted a detailed investigation on the perceived stressors of different demographic groups among construction workers. Empirical data were collected using a structured questionnaire in the Chinese construction industry. The empirical data were processed using both an independent sample t-test and an Analysis of Variance (ANOVA). The findings indicated that male workers reported greater workloads than did females. Married workers experienced more pandemic fear and job insecurity, and they were more sensitive to the poor working environment. Highly-educated workers were inclined to be more satisfied with organizational pandemic responses, and had lower job insecurity and role ambiguity, but they experienced heavier workloads. In addition, the differences in work experience and age were statistically significant with regards to job insecurity. This research contributes to the body of knowledge by giving a comprehensive understanding of demographic influences on perceived stressors among construction workers. It also provides valuable insights to identify sensitive demographic groups and promote their health and wellbeing during and after the pandemic

The Impact of Coworkers’ Safety Violations on an Individual Worker: A Social Contagion Effect within the Construction Crew

This research developed and tested a model of the social contagion effect of coworkers’ safety violations on individual workers within construction crews. Both situational and routine safety violations were considered in this model. Empirical data were collected from 345 construction workers in China using a detailed questionnaire. The results showed that both types of safety violations made by coworkers were significantly related to individuals’ perceived social support and production pressure. Individuals’ attitudinal ambivalence toward safety compliance mediated the relationships between perceived social support and production pressure and both types of individuals’ safety violations. However, safety motivation only mediated the effects of perceived social support and production pressure on individuals’ situational safety violations. Further, this research supported the differences between situational and routine safety violations. Specifically, we found that individuals were more likely to imitate coworkers’ routine safety violations than their situational safety violations. Coworkers’ situational safety violations had an indirect effect on individuals’ situational safety violations mainly through perceived social support and safety motivation. By contrast, coworkers’ routine safety violations had an indirect effect on individuals’ routine safety violations mainly through perceived production pressure and attitudinal ambivalence. Finally, the theoretical and practical implications, research limitations, and future directions were discussed

Soluble immune checkpoint-related proteins as predictors of tumor recurrence, survival, and T cell phenotypes in clear cell renal cell carcinoma patients

Background: Immune checkpoint inhibitors have achieved unprecedented success in cancer immunotherapy. With the exception of a few candidate biomarkers, the prognostic role of soluble immune checkpoint-related proteins in clear cell renal cell cancer (ccRCC) patients is largely uninvestigated. Methods: We profiled the circulating levels of 14 immune checkpoint-related proteins panel (BTLA, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, PD-L2, Tim-3, CD28, CD80, CD137, CD27 and CTLA-4) and their associations with the risk of recurrence and death in 182 ccRCC patients using a multiplex Luminex assay. Gene expression in tumors from a subset of participating patients (n = 47) and another 533 primary ccRCC from TCGA were analyzed to elucidate potential mechanisms. Our primary endpoint is overall survival; secondary endpoint is recurrence-free survival. Multivariate Cox proportional hazard model, unconditional logistic regression model, and Kaplan-Meier analysis were applied in the study. Results: sTIM3 and sLAG3 were significantly associated with advanced (stage III) disease (P \u3c 0.05). sPD-L2 was the strongest predictor of recurrence (HR 2.51, 95%CI 1.46-4.34, P = 9.33E-04), whereas high sBTLA and sTIM3 was associated with decreased survival (HR 6.02, 95%CI 2.0-18.1, P = 1.39E-03 and HR 3.12, 95%CI 1.44-6.75, P = 3.94E-03, respectively). Risk scores based on sTIM3 and sBTLA indicated that the soluble immune checkpoint-related proteins jointly predicted recurrence and death risks of ccRCC (P = 0.01 and 4.44E-04, respectively). Moreover, sLAG3 and sCD28 were found negatively correlated with cytolytic activity of T cells in tumors (rho = -0.31 and - 0.33, respectively). Conclusions: Our study provides evidence that soluble immune checkpoint-related proteins may associate with advanced disease, recurrence and survival in ccRCC patients, which highlights the prognostic values of soluble immune checkpoint-related proteins. Future independent validation in prospective studies is warranted

Circulating obesity-driven biomarkers are associated with risk of clear cell renal cell carcinoma: A two-stage, case-control study

Obesity is one of modifiable risk factors for clear cell renal cell cancer (ccRCC). We aim to identify the association between obesity-driven biomarkers and ccRCC risk. This is a retrospective, two-phase, case-control study involving 682 cases and 733 controls. Obesity-driven biomarkers [gastric inhibitory polypeptide (GIP), C-peptide, insulin, resistin, adipsin, peptide YY, pancreatic polypeptide, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1, monocyte chemoattractant protein 1, lipocalin2, leptin, adiponectin] were measured using the Milliplex method. Multivariate logistic regression was used to assess the associations between biomarkers and ccRCC risk. Results revealed that GIP, C-peptide, IL-6 and TNF-α levels were consistently distinct between cases and controls. These markers were significantly associated with ccRCC risk in both phases (except C-peptide). In the combined population, compared with individuals with low levels of the biomarkers, individuals with high level of GIP [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.40-0.67] had lower risk, whereas individuals with high levels of C-peptide (OR = 1.46, 95% CI: 1.15-1.87), IL-6 (OR = 2.20, 95% CI: 1.50-3.22), TNF-α (OR = 1.90, 95% CI: 1.49-2.43) had significantly higher risk. Stratified analysis showed consistent associations with ccRCC risk in most subgroups (P \u3c 0.05). The risk score based on the IL-6, TNF-α and GIP was positively associated with ccRCC risk in a dose-response manner (P for trend = 2.18E-13). Data from The Cancer Genome Atlas indicate that insulin signaling, IL-6 signaling and TNF-α signaling were enhanced in tumors. Collectively, our study demonstrates the integrative effect of insulin resistance and inflammation in ccRCC development, which may elucidate the basis of association between obesity and carcinogenesis. Further confirmation in prospective cohort studies are warranted for clinical applications in prevention and precision medicine of ccRCC

Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study

Background: The clinical predictors and biological mechanisms for localized prostate cancer (PCa) outcomes remain mostly unknown. We aim to evaluate the role of serum immune-checkpoint-related (ICK) proteins and genetic variations in predicting outcomes of localized PCa. Methods: We profiled the serum levels of 14 ICK-related proteins (BTLA, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, PD-L2, Tim-3, CD28, CD80, 4-1BB, CD27, and CTLA-4) in 190 patients with localized PCa. The genotypes of 97 single nucleotide polymorphisms (SNPs) from 19 ICK-related genes were analyzed in an extended population (N = 1762). Meta-data from ArrayExpress and TCGA was employed to validate and to probe functional data. Patients were enrolled and tumor aggressiveness, biochemical recurrence (BCR), and progression information were obtained. Statistical analyses were performed analyzing associations between serum biomarkers, genotypes, mRNA and outcomes. Results: We showed that serum (s)BTLA and sTIM3 levels were associated with PCa aggressiveness (P \u3c 0.05). sCD28, sCD80, sCTLA4, sGITR, sHVEM and sIDO correlated with both BCR and progression risks (all P \u3c 0.05). We further identified ICK variants were significantly associated with aggressiveness, BCR and progression. Among them, 4 SNPs located in CD80 (rs7628626, rs12695388, rs491407, rs6804441) were not only associated with BCR and progression risk, but also correlated with sCD80 level (P \u3c 0.01). rs491407 was further validated in an independent cohort. The CD80 mRNA expression was associated with BCR (HR, 1.85, 95% CI 1.06–3.22, P = 0.03) in meta-analysis of validation cohorts. Conclusion: We highlight the prognostic value of serum ICK-related proteins for predicting aggressiveness, BCR and progression of PCa. The genetic variations and mRNA expression in CD80 could be predictors and potential targets of localized PCa